Alessandro Bertolino Selected Research

D-Aspartic Acid (D Aspartate)

1/2022	Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain.
1/2018	The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies.
10/2017	Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity.
1/2017	Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients.
10/2013	Decreased levels of D-aspartate and NMDA in the prefrontal cortex and striatum of patients with schizophrenia.

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Alessandro Bertolino Research Topics

Disease

42	Schizophrenia (Dementia Praecox) 01/2022 - 09/2002
8	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 03/2003
6	Mental Disorders (Mental Disorder) 01/2022 - 04/2015
4	Bipolar Disorder (Manic Depressive Psychosis) 10/2021 - 05/2003
4	Parkinson Disease (Parkinson's Disease) 01/2019 - 02/2002
3	Brain Diseases (Brain Disorder) 10/2019 - 12/2007
3	Disease Progression 01/2019 - 01/2018
2	Inflammation (Inflammations) 01/2019 - 08/2015
1	Neurodevelopmental Disorders 01/2022
1	Depressive Disorder (Melancholia) 01/2021
1	Autism Spectrum Disorder 08/2020
1	Neurobehavioral Manifestations 01/2018
1	Pathologic Processes 01/2017
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2017
1	Hypoxia (Hypoxemia) 01/2016
1	Cognitive Dysfunction 01/2016
1	Alzheimer Disease (Alzheimer's Disease) 01/2016
1	Intellectual Disability (Idiocy) 08/2015
1	Major Depressive Disorder (Major Depressive Disorders) 04/2015
1	Blepharospasm 08/2011
1	Mood Disorders (Mood Disorder) 07/2004
1	Genetic Predisposition to Disease (Genetic Predisposition) 04/2003

Drug/Important Bio-Agent (IBA)

11	Biological ProductsIBA 01/2021 - 04/2003
10	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 02/2002
10	Antipsychotic Agents (Antipsychotics)IBA 01/2021 - 10/2004
10	Olanzapine (Zyprexa)FDA Link 01/2019 - 08/2004
7	Messenger RNA (mRNA)IBA 08/2020 - 08/2013
7	Biomarkers (Surrogate Marker)IBA 01/2019 - 04/2015
5	D-Aspartic Acid (D Aspartate)IBA 01/2022 - 10/2013
4	Serine (L-Serine)FDA Link 01/2022 - 11/2008
4	Amino Acids FDA Link 01/2022 - 11/2008
4	Proteins (Proteins, Gene)FDA Link 08/2015 - 11/2008
3	Pharmaceutical PreparationsIBA 01/2021 - 05/2009
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2017 - 10/2013
3	Protons (Proton)IBA 07/2004 - 03/2003
2	Aspartic Acid (Aspartate)FDA Link 01/2022 - 01/2017
2	Glutamic Acid (Glutamate)FDA Link 01/2022 - 08/2004
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2022 - 10/2013
2	Polytetrafluoroethylene (Teflon)FDA Link 01/2021 - 01/2019
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2016
2	Dopamine Receptors (Dopamine Receptor)IBA 09/2015 - 02/2009
2	Protein Isoforms (Isoforms)IBA 01/2014 - 05/2009
2	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 02/2009 - 12/2007
2	N-acetylaspartate (N-acetyl aspartate)IBA 07/2004 - 03/2003
1	Sp4 Transcription FactorIBA 01/2022
1	Glutamate Receptors (Glutamate Receptor)IBA 01/2022
1	Oxytocin Receptors (Oxytocin Receptor)IBA 08/2020
1	C-Reactive ProteinIBA 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 01/2019
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2019
1	LipidsIBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	MicroRNAs (MicroRNA)IBA 01/2019
1	Phencyclidine (Angel Dust)IBA 01/2018
1	Chlorpromazine (Thorazine)FDA Link 10/2017
1	Amitriptyline (Elavil)FDA LinkGeneric 10/2017
1	Bupropion (Wellbutrin)FDA LinkGeneric 10/2017
1	Haloperidol (Haldol)FDA LinkGeneric 10/2017
1	Fluoxetine (Prozac)FDA LinkGeneric 10/2017
1	Clozapine (Clozaril)FDA LinkGeneric 10/2017
1	serine racemaseIBA 01/2017
1	EnzymesIBA 01/2017
1	D-Aspartate OxidaseIBA 01/2017
1	A-factor (Streptomyces)IBA 01/2017
1	GTP-Binding Proteins (G-Protein)IBA 02/2016
1	ApolipoproteinsIBA 01/2016
1	Amyloid (Amyloid Fibrils)IBA 01/2016
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2016
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 08/2015
1	Psychotropic Drugs (Psychoactive Drugs)IBA 08/2015
1	Serotonin (5 Hydroxytryptamine)IBA 06/2015
1	ThymineIBA 01/2014
1	GuanineIBA 01/2014
1	Mirtazapine (Rexer)FDA LinkGeneric 12/2013
1	N-Methylaspartate (NMDA)IBA 10/2013
1	CateninsIBA 08/2013
1	Botulinum Toxins (Botulinum Toxin)IBA 08/2011
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 07/2011
1	3' Untranslated Regions (3' UTR)IBA 07/2011
1	Adenosine Monophosphate (AMP)IBA 01/2011
1	Cysteine (L-Cysteine)FDA Link 11/2008
1	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 10/2004
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 08/2004

Therapy/Procedure

2	Therapeutics 01/2018 - 02/2002
1	Treatment Delay 10/2021
1	Secondary Prevention 01/2021
1	Aftercare (After-Treatment) 01/2011
1	Behavior Control 01/2011